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Firstly, SOA (Substance of Abuse) Annual tests , which can be administered up to 10 times per month and tests for the following substances, as per the NFL: Cocaine Synthetic Marijuana Amphetamines (includes Adderall) Opiates Opioids PCP MDMA (i.e., ecstasy, molly) Related stories Secondly, players are also subject to PES (Performance Enhancing Substances) Annual tests , which can take place a maximum of 24 times a year